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| Tony Soprano | James Gandolfini | Big "T" himself |
| Carmela Soprano | Edie Falco | Tony's Wife |
| Meadow Soprano | Jamie Lynn Sigler | Tony & Carmela's daughter |
| Anthony Soprano Jr. | Robert Iler | Tony & Carmela's son |
| Livia Soprano | Nancy Marchand | Tony's mother |
| Dr. Jennifer Melfi | Lorraine Bracco | Tony's Psychiatrist |
| Corrado "Junior" Soprano | Dominic Chianese | Tony's Uncle |
| Jackie Aprile | Michael Rispoli | Mob Boss who died of Cancer |
| Rosalie Aprile | Sharon Angela | Wife/Widow of Jackie Aprile |
| Big Pussy Bompensero | Vincent Pastore | In Tony's Crew |
| Angie Bompenserio | Toni Kalem | Big Pussy's wife |
| Silvio Dante | Stevie Van Zandt | In Tony's Crew |
| Paulie Walnuts | Tony Sirico | In Tony's Crew |
| Christopher Moltisanti | Michael Imperioli | In Tony's Crew |
| Mikey Palmice | Al Sapienza | Works for Junior (dead now) |
| Artie Bucco | John Ventimiglia | Owner of Vensuvio's |
| Charmaine Bucco | Katherine Narducci | Wife of Artie |
| Hesh Rabkin | Jerry Adler | Long time advisor of the Sopranos |
| Vin Makasian | John Heard | Dectective who did jobs for Tony (dead now) |
| Brendan Filone | Anthony Desando | Worked with Christopher. Killed in season 1 |
| "Larry Boy" Barese | Tony Darrow | Boss and Ally of Tony's |
| Hunter Scangarelo | Michele DeCesare | Meadow's girlfriend |
| Father Phil | Paul Schulze | Priest |
| Dr. Cusamano | Robert Lupone | Tony's next door neighbor |
| Jean Cusamano | Angelica Torn | Wife of Dr. Cusamano |
| Mikey Palmice | Al Sapienza | Junior's boy. Killed in season#1 |
| Jimmy Altieri | Joseph Badalucco Jr. | Rat wearing a wire - dead now |
| Irina | Oksana Babiy | Tony's Russian mistress |
| Adriana | Drea De Matteo | Christopher's girlfriend |
| Isabella | Maria Grazia Cuccinotta | Appeared in Episode "Isabella" |
| Richie Aprile | David Proval | Jackie Aprile brother. |
| Annalisa | Sofia Milos | Daughter of Italian mob boss Zi Vittorio |
| Janice (Pravati) Soprano | Adia Turturro | Tony's sister |
| Johnny Sack | Vincent Curatola | Part of the NewYork family |